Talimogene Laherparepvec [TALI1]

Talimogene laherparepvec for treating unresectable metastatic melanoma

  1. I confirm that an application has been made and the first treatment will be prescribed and administered by a consultant specialist experienced in the treatment of melanoma
  2. I confirm this treatment will be given by a specialist trained to give intra-lesional injections of talimogene.
  3. I confirm the patient has cutaneous, subcutaneous or nodal deposit(s) of melanoma which is/are suitable for direct injection but is/are not surgically resectable.
  4. I confirm the patient has stage IIIb, stage IIIc or stage IVM1a disease according to the AJCC stage criteria of 2009 7th edition and if stage IVM1a disease (ie metastases to the skin, subcutaneous tissues or distant lymph nodes) has a normal serum LDH.
  5. I confirm the patient has no bone, brain, lung or any other visceral secondaries and if stage IVM1a disease, the serum LDH is not elevated.
  6. I confirm talimogene has been sanctioned by a specialist melanoma multidisciplinary team which includes an oncologist and a surgeon with expertise in the management of metastatic and locally advanced melanoma,
  7. I confirm that talimogene is appropriate for this patient as systemically administered immunotherapies or approved targeted therapies are not considered the best option by the specialist melanoma multidisciplinary team meeting which includes an oncologist and a surgeon with expertise in the management of metastatic and locally advanced melanoma, respectively.
  8. I confirm that talimogene will only be administered as a single agent and not in combination with systemic therapies eg chemotherapy, targeted agents or immunotherapy unless this is within the context of a Health Research Authority clinical trial.
  9. I confirm the patient will receive the licensed dose and frequency of talimogene laherparepvec

[NHS funded]{.badge .rounded-pill .bg-success} From: 28 December 2016

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CDF Managed Access: NA

NICE Technology Appraisal: TA410 (28 September 2016)

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