Belantamab mafodotin with pomalidomide and dexamethasone [BELA2]

Belantamab mafodotin with pomalidomide and dexamethasone as 2nd line treatment of relapsed or refractory myeloma in adult patients who previously received lenalidomide as part of 1st line systemic therapy where the following criteria have been met:

1. This application is being made by and the first cycle of systemic anti-cancer therapy will be prescribed by a consultant, or internally accredited haematology specialty trainee, specifically trained and assessed in the use of systemic anti-cancer therapy.
2. The patient has a confirmed diagnosis of multiple myeloma.

Note

Note: patients with amyloidosis or POEMS syndrome are not eligible for belantamab mafodotin.

3. This patient has received 1 and only 1 prior line of systemic therapy for myeloma and that the numbering of a line of treatment is in accordance with the International Myeloma Workshop Consensus recommendations for the uniform reporting of clinical trials (http://doi.org/10.1182/blood-2010-10-299487). A line of therapy is defined as one or more cycles of a planned treatment program. This may consist of one or more planned cycles of single-agent therapy or combination therapy, as well as a sequence of treatments administered in a planned manner (eg 1st line induction chemotherapy/chemotherapies when followed by stem cell transplantation and maintenance therapy is considered as 1 line of therapy). A new line of therapy starts when a planned course of therapy is modified to include other treatment agents (alone or in combination) as a result of disease progression, relapse or toxicity, the exception to this being the need to attain a sufficient response for stem cell transplantation to proceed. A new line of therapy also starts when a planned period of observation off therapy is interrupted by a need for additional treatment for the disease.

Note

Note: although the marketing authorisation is for patients with myeloma who have had at least one prior therapy including lenalidomide, the company has initially sought a NICE recommendation for patients who have had only one prior line of treatment. Patients who have had more than one prior line of therapy are not eligible for treatment with this belantamab mafodotin combination.

4. This patient has been previously treated with a 1st line lenalidomide containing regimen which is commissioned by NHS England or is part of a 1st line treatment regimen in a NIHR-badged clinical trial. Please confirm below which 1st line treatment was received by the patient:

• 1st line daratumumab plus lenalidomide and dexamethasone for transplant ineligible disease
• 1st line lenalidomide and dexamethasone for transplant ineligible disease
• maintenance lenalidomide post stem cell transplant as part of 1st line therapy
• lenalidomide was part of a 1st line treatment regimen in a NIHR-badged clinical trial
• 1st line isatuximab plus bortezomib, lenalidomide and dexamethasone for untreated multiple myeloma when a stem cell transplant is unsuitable

Note

Note: patients who have not received lenalidomide as part of their 1st line therapy are not eligible for treatment with this belantamab mafodotin combination.

5. The reason for discontinuing the 1st line lenalidomide was because of either disease progression on treatment or intolerance of lenalidomide. Please indication the reason for discontinuing the 1st line lenalidomide:

• disease progression on treatment or
• intolerance of lenalidomide

6. This patient has been previously treated with bortezomib or another proteasome inhibitor as part of 1st line therapy. Please tick the appropriate box which applies to this patient:

• No, the patient has not been previously treated with bortezomib or any other proteasome inhibitor or
• Yes, the patient has been previously treated with a 1st line bortezomib-containing regimen or
• Yes, the patient has been previously treated with another 1st line proteasome inhibitor containing regimen in a clinical trial

7. This patient has been previously treated with an anti-CD38 antibody as part of 1st line therapy. Please tick the appropriate box which applies to this patient:

• No, the patient has not been previously treated with an anti-CD38 antibody or
• Yes, the patient has been previously treated with a 1st line anti-CD38 antibody or
• Yes, the patient has been previously treated with another 1st line anti-CD38 antibody containing regimen in a clinical trial

8. The patient has been previously treated as part of 1st line therapy with stem cell transplantation. Please tick the appropriate box which applies to this patient:

• No, the patient has not been previously treated as part of 1st line treatment with stem cell transplantation or
• Yes, the patient has been previously treated as part of 1st line treatment with stem cell transplantation

9. The patient has progressive disease during or following 1st line systemic anti-myeloma therapy.
10. The patient has an ECOG performance status of 0 or 1 or 2: Please record below the patient’s ECOG performance status:

• PS 0 or
• PS 1 or
• PS 2

11. Belantamab mafodotin will be used only in combination with pomalidomide and dexamethasone and not with any other anti-myeloma agents.
12. The patient will be treated with belantamab mafodotin until disease progression or the occurrence of excessive toxicity or the withdrawal of patient consent, whichever is the sooner.
13. The prescribing clinician understands that given the potentially necessary frequency and duration of treatment breaks during treatment with belantamab mafodotin, this indication is exempt from NHS England’s treatment break policy.

Note

Note: if there is disease progression during a treatment break from belantamab mafodotin, treatment with belantamab mafodotin must be discontinued.

14. The use of belantamab mafodotin will otherwise be as described in the drug’s Summary of Product Characteristics (SPC).

NHS funded From: 19 May 2026

Additional information

Form version: -

CDF Managed Access: NA

NICE Technology Appraisal: TA1133 (18 February 2026)

Current Form Version

Note

The data on this page was produced using version 1.398 of the CDF list, downloaded from NHS England’s website on 20 May 2026 at 18:00.

If NHS England has published a new version of the CDF List but this site has not yet accessed that, this form may be out of date. Additionally, if any update has occurred without NHS England noting it as a change, this page will be out of date.

Older Form Versions

There are previous versions of this form. These may not all be available on this site.

• BELA2_prior_to_cdf_1.398