Published

May 16, 2025

Blinatumomab [BLI2]

The treatment of relapsed/refractory Philadelphia negative B-precursor acute lymphoblastic leukaemia in CHILD patients

  1. An application is being made and the first cycle of systemic anti-cancer therapy with blinatumomab will be prescribed by a consultant specialist specifically trained and accredited in the use of systemic anti-cancer therapy.
  2. The patient is a child and ONE of the following applies: OPTION 1 - The patient is post pubescent. OPTION 2 - The patient is pre pubescent Please choose correct option
  • Option A
  • Option B NB. There is a separate Blueteq form to be used for blinatumomab in this indication in adults.
  1. The patient has relapsed or refractory Philadelphia negative acute lymphoblastic leukaemia (ALL).
  2. The patient has been previously treated with intensive combination chemotherapy as initial treatment with or without subsequent salvage therapy.
  3. Blinatumomab is being requested by and administered in principal treatment centres only.
  4. The use of the blinatumomab has been discussed at a multidisciplinary team (MDT) meeting which must include at least two consultants in the subspecialty with active and credible expertise in the relevant field of whom at least one must be a consultant paediatrician. The MDT should include a paediatric pharmacist and other professional groups appropriate to the disease area.
  5. The patient has a performance status of 0 - 2.
  6. A maximum of 5 cycles of treatment with blinatumomab will be administered.
  7. The use of blinatumomab in this indication is exempt from the NHS England Treatment Break policy.
  8. Trust policy regarding unlicensed treatments has been followed as blinatumomab is not fully licensed in this indication in children.
  9. Blinatumomab should otherwise be used as set out in its Summary of Product Characteristics (SPC).

NHS funded From: 26 September 2017

Form version:

CDF Managed Access: NA

NICE Technology Appraisal: TA450 (27 April 2017)

Current Form Version

Note

The data on this page was produced using version 1.363 of the CDF list, downloaded from an archive of NHS England’s website on 16 May 2025 at 14:00.

If NHS England has published a new version of the CDF List but this site has not yet accessed that, this form may be out of date. Additionally, if any update has occurred without NHS England noting it as a change, this page will be out of date.

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