Dostarlimab in combination with platinum-containing chemotherapy (carboplatin and paclitaxel) [DOS3]

For the 1st line treatment of mismatch repair proficient (pMMR) or microsatellite stable endometrial carcinoma in adult patients who have recurrent or primary advanced disease and who are not candidates for potentially curative surgery or radiotherapy or chemoradiotherapy but are eligible for systemic therapy where the following criteria have been met:

1. Both this application is being made by and the first cycle of systemic anti-cancer therapy with dostarlimab in combination with carboplatin and paclitaxel will be prescribed by a consultant specialist specifically trained and accredited in the use of systemic anti-cancer therapy.
2. The patient has a histologically- or cytologically confirmed diagnosis of endometrial carcinoma (including clear cell and serous histologies).

Note

Note: patients with carcinosarcoma (Mixed Mullerian tumour) are eligible but otherwise uterine sarcomas of any kind are NOT eligible for dostarlimab in this indication.

3. The patient’s tumour has a documented presence of mismatch repair proficiency (pMMR) or microsatellite stability confirmed by validated testing.
4. Either the patient has a 1st recurrence of endometrial carcinoma after surgery or radiotherapy or chemoradiotherapy or has presented with primary locally advanced or metastatic endometrial carcinoma and in whichever scenario is not a candidate for any potentially curative treatment with surgery or radiotherapy or chemoradiotherapy. Please mark below which scenario applies to this patient:

• 1st recurrence after previous surgery, radiotherapy or chemoradiotherapy or
• presented with primary stage IIIA disease and has received no systemic therapy or
• presented with primary stage IIIB disease and has received no systemic therapy or
• presented with primary stage IIIC1 disease and has received no systemic therapy or
• presented with primary stage IIIC2 disease and has received no systemic therapy or
• presented with primary stage IV disease and has received no systemic therapy

5. Either the patient has not previously received any systemic chemotherapy for the endometrial carcinoma, or the only systemic therapy has been as neoadjuvant or adjuvant chemotherapy or chemoradiotherapy and the patient has progressed or recurred at least 6 months since the completion of such chemotherapy. Please mark below which scenario applies to this patient:

• the patient is treatment-naïve to chemotherapy for the endometrial cancer or
• the only systemic therapy has been as neoadjuvant or adjuvant chemotherapy or chemoradiotherapy and the patient has progressed or recurred at least 6 months since the completion of such chemotherapy

6. Dostarlimab will be given in combination with carboplatin and paclitaxel unless there is a clear contraindication to the use of one or both cytotoxic agents. Please mark below which scenario applies to this patient:

• the intent is to use the combination of carboplatin and paclitaxel as the chemotherapy partner to dostarlimab or
• the patient has a clear contraindication to the use of carboplatin and/or paclitaxel and hence an alternative platinum-based combination therapy must be used as the chemotherapy partner to dostarlimab

Note

Note: in patients who suffer a severe allergic reaction to paclitaxel or carboplatin which necessitates discontinuation of the drug causing the severe allergy, use of dostarlimab can continue with carboplatin or paclitaxel in combination with whichever agent is considered appropriate by the clinician.

7. Unless the patient is contraindicated from starting with carboplatin and paclitaxel, the patient will commence combination chemotherapy with carboplatin at a dose of AUC 5mg/ml/min and paclitaxel at 175mg/m², planned to be given 3-weekly and for a maximum of 6 cycles of chemotherapy.
8. The patient has not received any prior antibody treatment which targets PD-1 or PD-L1 or PD-L2 or CD137 or OX40 or anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) unless the patient has already received dostarlimab for the same indication via a company sponsored early access scheme Please mark below which scenario applies to this patient:

• the patient has not received any prior antibody treatment which targets PD-1 or PD-L1 or PD-L2 or CD137 or OX40 or anti-cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) or
• the patient has received dostarlimab for the same indication via a company sponsored early access scheme and meets all other criteria on this form

9. Treatment with dostarlimab will be stopped at whichever of the following events occurs first: disease progression, or loss of clinical benefit, or unacceptable toxicity, or withdrawal of patient consent, or after a maximum of 3 calendar years of treatment.
10. The patient has an ECOG performance status (PS) of 0 or 1.
11. The patient has no symptomatically active brain metastases or leptomeningeal metastases.
12. When a treatment break of more than 12 weeks beyond the expected 3- or 6-weekly cycle length is needed, the prescribing clinician will complete a treatment break approval form to restart treatment.
13. Dostarlimab will be otherwise used as set out in its Summary of Product Characteristics (SPC).

CDF funded From: 25 November 2025

Additional information

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The data on this page was produced using version 1.379 of the CDF list, downloaded from NHS England’s website on 26 November 2025 at 18:00.

If NHS England has published a new version of the CDF List but this site has not yet accessed that, this form may be out of date. Additionally, if any update has occurred without NHS England noting it as a change, this page will be out of date.

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