Fruquintinib [FRU1]

Fruquintinib for patients with either metastatic or and inoperable colorectal cancer who have received anticancer treatment regimens including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies anti-VEGF agents and/or anti-EGFR-based agents combination of trifluridine plus tipiracil and bevacizumab unsuitable where the following criteria have

1. This application is both being made by and the first cycle of systemic anti-cancer therapy with fruquintinib will be prescribed by a consultant specialist specifically trained and accredited in the use of systemic anti-cancer therapy.
2. The patient has a histologically confirmed diagnosis of adenocarcinoma of the colon or rectum.
3. The patient has either metastatic disease or locally advanced and inoperable disease.
4. The patient has been previously treated for metastatic or locally advanced and inoperable disease with 2 or more prior anticancer regimens including fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapies. If disease has recurred during, or within, 6 months after the last administration of neoadjuvant or adjuvant therapy, this can be counted prior line of treatment for metastatic or locally advanced and inoperable disease.

Note

Note: the regimens of either FOLFIRINOX or FOLFOXIRI can be counted as 2 chemotherapy regimens.

5. The patient has been previously treated with anti-EGFR-containing chemotherapy or not. Please tick which option applies to this patient:

• yes, the patient has been previously treated with anti-EGFR-containing chemotherapy or
• no, the patient has not been previously treated with anti-EGFR-containing chemotherapy

6. The patient has been previously treated with an anti-VEGF-containing chemotherapy or not. Please tick which option applies to this patient: locally advanced - yes, the patient has been previously treated with an anti-VEGF-containing chemotherapy or 2 or more prior

• no, the patient has not been previously treated with an anti-VEGF-containing chemotherapy

7. The patient has been previously treated with regorafenib or not. with or without AND for whom the Please tick which option applies to this patient: is

• yes, the patient has been previously treated with regorafenib or been met:
• no, the patient has not been previously treated with regorafenib

8. The patient is unsuitable for treatment with the combination of trifluridine plus tipiracil and bevacizumab for one of the reasons listed below – please tick the appropriate box:

• the patient has already been treated with the combination of trifluridine plus tipiracil and bevacizumab or
• the patient has already been treated with trifluridine plus tipiracil or
• the patient has a contraindication to treatment with trifluridine plus tipiracil or
• the patient has a contraindication to bevacizumab or
• the patient has previously had poor or no responses to cytotoxic therapy and hence further treatment with cytotoxic chemotherapy is considered inappropriate or
• the patient has previously tolerated cytotoxic chemotherapy poorly and hence further treatment with cytotoxic chemotherapy is inappropriate

9. The patient has not been previously treated with fruquintinib unless transferring from a company early access scheme and all other treatment criteria on this form are fulfilled.
10. The patient has an ECOG performance status of 0 or 1.
11. Fruquintinib is to be used as monotherapy.
12. Fruquintinib is to be continued until loss of clinical benefit or unacceptable toxicity or patient choice to stop treatment, whichever is the sooner.
13. When a treatment break of more than 6 weeks beyond the expected 4-weekly cycle length is needed, I will complete a treatment break approval form to restart treatment.
14. Fruquintinib will be otherwise used as set out in its Summary of Product Characteristics (SPC).

CDF funded From: 03 July 2025 - anticipated to move to NHS funding: 21 October 2025

Additional information

Form version: -

CDF Managed Access: Yes

NICE Technology Appraisal: NA (NA)

Current Form Version

Note

The data on this page was produced using version 1.372 of the CDF list, downloaded from NHS England’s website on 23 August 2025 at 23:36.

If NHS England has published a new version of the CDF List but this site has not yet accessed that, this form may be out of date. Additionally, if any update has occurred without NHS England noting it as a change, this page will be out of date.

Older Form Versions

There are previous versions of this form. These may not all be available on this site.

• FRU1_prior_to_cdf_1.372