Tisotumab vedotin [TISV1]

For treating recurrent or metastatic cervical cancer that has progressed on or after systemic treatment where the following criteria have been met:

1. This application is being made by and the first cycle of systemic anti-cancer therapy will be prescribed by a consultant, or internally accredited oncology specialty trainee, specifically trained and assessed in the use of systemic anti-cancer therapy.
2. This patient has a histological diagnosis of recurrent or metastatic cervical cancer, and has exhibited disease progression, either whilst receiving, or after treatment with, systemic chemotherapy.

Note

Note: The histology must be either squamous, adenocarcinoma, or adenosquamous.

3. This patient has received either ONE or TWO prior lines of systemic treatment for their recurrent/metastatic cervical cancer. Please mark below how many prior lines of treatment have been received:

• ONE prior line
• TWO prior lines

4. The patient has an ECOG performance status of 0 or 1 Please mark below the performance status of the patient:

• ECOG PS 0
• ECOG PS 1

5. Treatment with tisotumab vedotin will be given until disease progression, unacceptable toxicity, or withdrawal of patient consent, whichever of these events occurs first.
6. The prescribing clinician understands that given the potentially necessary frequency and duration of treatment breaks during treatment with tisotumab vedotin, this indication is exempt from NHS England’s treatment break policy

Note

Note: if there is disease progression during a treatment break from tisotumab vedotin, treatment with tisotumab vedotin must be discontinued.

7. The use of tisotumab vedotin will be otherwise used as per its Summary of Product Characteristics (SPC).

CDF funded From: 21 May 2026

Additional information

Form version: -

CDF Managed Access: No

NICE Technology Appraisal: NA (NA)

Current Form Version

Note

The data on this page was produced using version 1.399 of the CDF list, downloaded from NHS England’s website on 21 May 2026 at 18:00.

If NHS England has published a new version of the CDF List but this site has not yet accessed that, this form may be out of date. Additionally, if any update has occurred without NHS England noting it as a change, this page will be out of date.

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